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Remarkable New Research About Stress and the Brain

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Remarkable New Research About Stress and the Brain

In a perfect world, stress would come with an adjustable dial. And there would be six day weekends. And coffee, beds and breakfasts would make themselves. What we lack in adjustable dials and the automated making of beautiful things, we make up for in creativity and adaptability, and a profound capacity to protect ourselves from the assault of stress. 

We might not be able to stop the stress, but we can stop it causing ruin. New research explains why giving ourselves priority needs to become less of an option and more of a must do.

Relationships, money, children, work, and day to day life stress mean that it’s not always possible to adjust the volume and intensity of stress in our lives. What we can do is manage it, but tending to our own needs often doesn’t make it anywhere near the ‘must do’ list, hovering instead on the ‘maybe one day when I get a cheque six million dollars and don’t have to work or buy my own groceries’ list. If you have ever needed a reason to get serious about taking time out to de-stress, remarkable new research has something for you.

Stress and the brain. What they found.

The research by Rockefeller University was conducted on mice, but don’t let that take anything away from the findings and what they mean for us humans. Mice are often used in studies because they are so genetically, biologically and physiologically close to humans. 

In the study, published in the journal, Molecular Psychiatry, researchers exposed the mice to chronic stress by keeping them in a small space for 21 days. They then looked at the mice to see which of their behaviours had changed. They were also interested to see whether there were any changes in the brain cells within the three different areas of the amygdala, the part of the brain that regulates emotions such as fear and anxiety. 

The exposure to chronic stress caused changes in the amygdala. These changes have been associated with anxiety and depression. 

In the first area of the amygdala the researchers looked at, the stress did not appear to cause any noticeable changes.

In the second area, they noticed the branches of the cells had become longer and more complex. This is a healthy change and points to the ability of the mice to adapt to certain environments.

In the third area, they noticed shrinkage of the branches that connected with other parts of the brain. This change is a worrying one. When these crucial connections are lost, the brain is less able to adapt to new experiences. Effectively, it becomes trapped in an anxious or depressed state.

Protecting the Brain.

The research also highlighted a new experimental drug that might protect the brain against these changes. 

‘While this rewiring from chronic stress can contribute to disorders such as anxiety and can contribute to disorders such as anxiety and depression, our experiments with mice showed that the neurological and behavioral effects of stress can be prevented with treatment by a promising potential antidepressant that acts rapidly.’ Carla Nasca, researcher.

The treatment that was used to protect against the effects of chronic stress was acetyl carnitine, a molecule that is being explored for its potential as a rapid-acting antidepressant. The mice who were treated with this drug were more sociable and showed less adverse brain changes, than the stressed mice who weren’t treated. Humans and mice both naturally produce acetyl carnitine. Animals that are more vulnerable to depression show a deficiency in acetyl carnitine. Researchers are looking into whether people with depression show the same abnormally low levels.  

Here’s the rub. As with any physiological symptom, the symptoms of stress are a sign that something needs changing. Chronic stress is a sign that the environment is drawing on more emotional, physical and/or physiological resources than you have. 

The promise of the experimental medication is that is will protect the brain from the neurological effects of stress that we know about, but it doesn’t get rid of the stress. Stress has other effects on the body and mind, outside the brain.

Of course, it’s not always possible to change your life, which is why protecting your whole self from the effects of stress is so important. Medication may be one part of the answer, but it’s certainly not all of it, nor is it the only one. 

If I can’t reduce stress in my life, what then?

Ok. So you can’t leave you job, your relatives, your bills, the traffic and the nailbiting ups and downs of The Great British Bake Off (for the love of lemons why does anyone have to leave?) – what can you do instead?

A powerful way to protect against stress is to reframe it. Research from Harvard has found that reframing stress as helpful rather than harmful can reverse the physiological changes brought about by stress. 

In a massive study that involved almost 30,000 people, researchers found that people who experienced high stress and who believed that it was harmful for them, had a 43% increase in the risk of premature death. However – people who were highly stressed but didn’t believe that it would harm them had a risk of premature death that was even lower than people who claimed they had a pretty low-stress existence.

And finally …

Stress and modern living often tend to come as a bundle. If we can’t change the stressors that cozy up beside us day after day, we need to change the way we deal with them. There are many life-giving ways to put back what stress takes out, including exercise, reframing the way we think about stress, sleeping, playing, connecting with our crew, listening to music, or meditating. The challenge then, becomes finding ways or opportunities to become our own priority from time to time. Life opens up when we love ourselves as much as we love the ones close to us.

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15 Comments

Monique

Just in time before my first psychotherapy appointment on Monday. Thank you Karen, this is most helpful.
I was always convinced that stress and depression are connected, and if the biggest stressors were removed, the depression would not flare up.
Despite my depression being there constantly, the absolute lowness of spirits only becomes apparent if there are too many stressful episodes happening at the same time, or so close together that I cannot deal with them simultaneously.
Could it be that just one simple chemical was able to restore the balance?
If so, it would be marvellous – I hate the idea of antidepressants and how they alter personality.

Reply
Hey Sigmund

You’re welcome Monique. I’m pleased the article found it’s way to you when it did. Stress can certainly feed into depression. There is definitely a link there. A lot of research is looking at depression as being caused by systemic inflammation, which stress can contribute to. Here is an article that explains that http://www.heysigmund.com/new-research-will-change-way-think-depression/. This is why lifestyle factors, such as exercise, eating the right food to support brain health, reducing stress, sleep, sunlight, social connection, meditation etc are all important for mental health and keeping the vital neurochemicals at healthy levels. Even doing these things though, sometimes depression can happen, so there is still a lot we need to learn about the causes. There is a lot of work happening in the area, which is great news. Hopefully some answers and a reliable, effective way to treat depression aren’t too far away.

Reply
Debbie

Would like to have heard of some more natural ways to reduce stress other than medication. Those areas should always be introduced first. Medication should always be a last resort.

Reply
Hey Sigmund

Debbie there are a number of articles on the site that talk about the natural ways to reduce stress. The scope of this article was this piece of research that explored the effects of stress on the brain. As part of that research, they looked at the effect of a particular medication on those changes in the brain but as the article points out, there are other considerations in relying on medication to turn around the effects of stress on the brain. At the bottom of the article is a suggested article, ‘How to be Mindfully Selfish and why It’s So Important’. This article discusses medication-free ways to manage stress.

Reply
Robert Hammel (The Unhappy Psychologist)

“Stress and modern living often tend to come as a bundle”

Absolutely! Stress & emotional reactions are an integral part of our being human. We stress, therefore we are. Stress means we’re alive!

Like the article notes though. It’s how we interpret and manage the stress that’s most important. Like the Godfather of stress Hans Selye said decades ago:

“It’s not stress that kills us, it is our reaction to it”.

Thanks for the great article.

Reply
Michelle

Great Article! We forget in the intensity of stress that little things can help us feel better and making deliberate steps to put them in place is sometimes needed. Thanks for keeping these coming – there’s always something for everyone. I look forward to my Friday in-box!

Reply
Leonor

work stress, bullying at the job by co-workers….etc. how does that affect a person’s brain and body?

Reply
Leonor

I also meant to ask about voice decibel levels A co-worker who is at the front desk (my office is next to it) literally screeches at the top of her lungs day in and day out. how does that affect brain and body function?

Reply
Barb

What I love about the viewpoints of these articles is the positive slant on things. Many of us have -including me -come from a very dysfunctional and psyche damaging environment leaving us with a constant “flight or fight” reaction to most things. The exciting and promising part of the brain is in its plasticity and ability to alter pathways to a brain able to heal and cope better. It’s not an easy task and I wholeheartedly embrace the self love ideology towards oneself to offset situations that aren’t easily changed. A 10 minute break at a park or an outdoor patio gives us that often overlooked but oh so necessary recharge. Today -I’m getting my hair done and going for a iced lime slushy drink at my fave diner. Remember to be good to you??

Reply
Colin Stone, Relaxation Therapist

And so much of what we stress about is imagined in our mind. The mind is such an awesome resource, and our imagination is best used to rehearse positive outcomes. Why waste our power on negative thinking? Ten minutes a day in mental rehearsal (how might today turn out if everything goes great?) can give us such a huge boost – without drugs! Try this for just three days in a row and see what happens!

Reply
Andrea

quite understandable and pretty informative…..like the article,because I’ve been also suffering from stress…keep sharing more article about stress….Thank you for your lovely article .

Reply

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