Compelling Research Discovers A Potential Cause of Depression Symptoms

Research Finds Possible New Direction for Treatment of Depression

Compelling new research has discovered a previously unknown cause of depression, opening way for new potential new treatment pathways. The significance of this enormous as over half of all people who have major depression are not able to find relief from antidepressants. 

There is no single known cause of depression but we do know that it takes more than one biological change to trigger an episode.

Inflammation in the brain seems to be one of these changes, with new research finding a compelling link between brain inflammation and major depression.

Brain scans were compared between people with clinical depression and those without. The scans revealed that brain inflammation in people with depression was 30% more than those without. The inflammation was highest in those people who were experiencing the most severe depression.

Inflammation in the brain serves a similar protective function as it does in the rest of the body, but too much can be damaging.

Evidence is increasingly pointing to the role of inflammation in generating the symptoms of major depression such as low mood and appetite and sleep disturbances. The role of brain inflammation on clinical depression seems to be independent of any other physical illness.

The findings have significant implications for the development of new treatments. Lead researcher Dr Jeffrey Meyer explains, ‘It provides a potential new target to either reverse the brain inflammation or shift to a more positive repair role, with the idea that it would alleviate symptoms.’

Our knowledge of depression and its possible causes is expanding all the time, opening new paths and possibilities for effective treatments.

Like so many illnesses, depression draws a circle around one person and draws those who are close to that person in. See here for what to do when someone you care about has depression.

4 Comments

Wanda

I have thoroughly enjoyed your articles on depression and anxiety in children. Is this anxiety in children more prevalent in boys or girls or the same? Thank you so much for your insight.

Reply
heysigmund

I’m so pleased you’ve enjoyed the articles. Now about the prevalence in boys and girls, it depends on what sort of anxiety. Social anxiety and separation anxiety are more common in girls. Girls are also twice as likely as boys to have panic attacks. Girls are also more likely to develop generalised anxiety disorder – about 2 in 3 are girls. Obsessive compulsive disorder are about equal. Hope this helps.

Reply
Clara McBride

It seems inflammation is being connected to so many of our health problems. Will the same dietary changes recommended for inflammation in other parts of our body help reduce inflammation in our brains as well?

Reply
heysigmund

This such a good question. This research is in its very early days and researchers are still exploring the implications. There are many connections being made between diet and mental health. I’ll certainly be following the research and posting about it. Thank you for making contact with me.

Reply

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We’re in charge of keeping them, others, and their relationship with us safe. They’re in charge of how they respond.

It’s why boundaries have to be about what we do - because it’s all we can control.

Sometimes an anchor presence means recognising that we can’t stop the storm, and we don’t need to.

When they don’t have the skills or resources to do what we would like them to do in the moment, we do what we can do to keep the moment safe, while letting them know we are here for them.

If they’re hurting a sibling, we move the sibling away, and stay in connection while we do. ‘It’s okay to be angry. I won’t let you hurt their body (while we’re physically moving their sibling - that’s the boundary). I’m right here (relationship).’

Or if they’re yelling: ‘I want to hear what you want. I care about you much to listen when you’re saying those things about me. (Boundary - I’m not listening.) 

Or, ‘You might stay angry with me for a while and that’s okay. I’m here when you want to talk about it, but I won’t listen while you’re yelling at me. Take your time. You’re not in trouble.’♥️
Mattering is about feeling valued and feeling like I’m doing something that adds value. It doesn’t have to come from grades or schoolwork, and for so many kids it probably won’t. There are so many ways to help kids feel seen and valued that have nothing to do with schoolwork, but which can work to engage them in schoolwork. Little things make a big difference. 

We also have to let our teachers know how much the matter. They are the greatest key to ‘mattering’ (or unmattering) in our schools and for our young people.♥️
If we want to meet their learning needs, we first have to meet their relational ones. If we want them to be open to learning, they first have to open to the adult they are learning from - and they won’t be open if they don’t feel seen, safe, and cared for. It’s not always easy, it’s just how it is.♥️
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