Compelling Research Discovers A Potential Cause of Depression Symptoms

Research Finds Possible New Direction for Treatment of Depression

Compelling new research has discovered a previously unknown cause of depression, opening way for new potential new treatment pathways. The significance of this enormous as over half of all people who have major depression are not able to find relief from antidepressants. 

There is no single known cause of depression but we do know that it takes more than one biological change to trigger an episode.

Inflammation in the brain seems to be one of these changes, with new research finding a compelling link between brain inflammation and major depression.

Brain scans were compared between people with clinical depression and those without. The scans revealed that brain inflammation in people with depression was 30% more than those without. The inflammation was highest in those people who were experiencing the most severe depression.

Inflammation in the brain serves a similar protective function as it does in the rest of the body, but too much can be damaging.

Evidence is increasingly pointing to the role of inflammation in generating the symptoms of major depression such as low mood and appetite and sleep disturbances. The role of brain inflammation on clinical depression seems to be independent of any other physical illness.

The findings have significant implications for the development of new treatments. Lead researcher Dr Jeffrey Meyer explains, ‘It provides a potential new target to either reverse the brain inflammation or shift to a more positive repair role, with the idea that it would alleviate symptoms.’

Our knowledge of depression and its possible causes is expanding all the time, opening new paths and possibilities for effective treatments.

Like so many illnesses, depression draws a circle around one person and draws those who are close to that person in. See here for what to do when someone you care about has depression.

4 Comments

Wanda

I have thoroughly enjoyed your articles on depression and anxiety in children. Is this anxiety in children more prevalent in boys or girls or the same? Thank you so much for your insight.

Reply
heysigmund

I’m so pleased you’ve enjoyed the articles. Now about the prevalence in boys and girls, it depends on what sort of anxiety. Social anxiety and separation anxiety are more common in girls. Girls are also twice as likely as boys to have panic attacks. Girls are also more likely to develop generalised anxiety disorder – about 2 in 3 are girls. Obsessive compulsive disorder are about equal. Hope this helps.

Reply
Clara McBride

It seems inflammation is being connected to so many of our health problems. Will the same dietary changes recommended for inflammation in other parts of our body help reduce inflammation in our brains as well?

Reply
heysigmund

This such a good question. This research is in its very early days and researchers are still exploring the implications. There are many connections being made between diet and mental health. I’ll certainly be following the research and posting about it. Thank you for making contact with me.

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Separation anxiety can come with a tail whip - not only does it swipe at kids, but it will so often feel brutal for their important adults too.

If your child struggle to separate at school, or if bedtimes tougher than you’d like them to be, or if ‘goodbye’ often come with tears or pleas to stay, or the ‘fun’ from activities or play dates get lost in the anxiety of being away from you, I hear you.

There’s a really good reason for all of these, and none of them have anything to do with your parenting, or your child not being ‘brave enough’. Promise. And I have something for you. 

My 2 hour on-demand separation anxiety webinar is now available for purchase. 

This webinar is full of practical, powerful strategies and information to support your young person to feel safer, calmer, and braver when they are away from you. 

We’ll explore why separation anxiety happens and powerful strategies you can use straight away to support your child. Most importantly, you’ll be strengthening them in ways that serve them not just for now but for the rest of their lives.

Access to the recording will be available for 30 days from the date of purchase.

Link to shop in bio. 

https://www.heysigmund.com/products/separation-anxiety-how-to-build-their-brave/
The more we treat anxiety as a problem, or as something to be avoided, the more we inadvertently turn them away from the safe, growthful, brave things that drive it. 

On the other hand, when we make space for anxiety, let it in, welcome it, be with it, the more we make way for them to recognise that anxiety isn’t something they need to avoid. They can feel anxious and do brave. 

As long as they are safe, let them know this. Let them see you believing them that this feels big, and believing in them, that they can handle the big. 

‘Yes this feels scary. Of course it does - you’re doing something important/ new/ hard. I know you can do this. How can I help you feel brave?’♥️
I’ve loved working with @sccrcentre over the last 10 years. They do profoundly important work with families - keeping connections, reducing clinflict, building relationships - and they do it so incredibly well. @sccrcentre thank you for everything you do, and for letting me be a part of it. I love what you do and what you stand for. Your work over the last decade has been life-changing for so many. I know the next decade will be even more so.♥️

In their words …
Posted @withregram • @sccrcentre Over the next fortnight, as we prepare to mark our 10th anniversary (28 March), we want to re-share the great partners we’ve worked with over the past decade. We start today with Karen Young of Hey Sigmund.

Back in 2021, when we were still struggling with covid and lockdowns, Karen spoke as part of our online conference on ‘Strengthening the relationship between you & your teen’. It was a great talk and I’m delighted that you can still listen to it via the link in the bio.

Karen also blogged about our work for the Hey Sigmund website in 2018. ‘How to Strengthen Your Relationship With Your Children and Teens by Understanding Their Unique Brain Chemistry (by SCCR)’, which is still available to read - see link in bio.

#conflictresolution #conflict #families #family #mediation #earlyintervention #decade #anniversary #digital #scotland #scottish #cyrenians #psychology #relationships #children #teens #brain #brainchemistry #neuroscience
I often go into schools to talk to kids and teens about anxiety and big feelings. 

I always ask, ‘Who’s tried breathing through big feels and thinks it’s a load of rubbish?’ Most of them put their hand up. I put my hand up too, ‘Me too,’ I tell them, ‘I used to think the same as you. But now I know why it didn’t work, and what I needed to do to give me this powerful tool (and it’s so powerful!) that can calm anxiety, anger - all big feelings.’

The thing is though, all powertools need a little instruction and practice to use them well. Breathing is no different. Even though we’ve been breathing since we were born, we haven’t been strong breathing through big feelings. 

When the ‘feeling brain’ is upset, it drives short shallow breathing. This is instinctive. In the same ways we have to teach our bodies how to walk, ride a bike, talk, we also have to teach our brains how to breathe during big feelings. We do this by practising slow, strong breathing when we’re calm. 

We also have to make the ‘why’ clear. I talk about the ‘why’ for strong breathing in Hey Warrior, Dear You Love From Your Brain, and Ups and Downs. Our kids are hungry for the science, and they deserve the information that will make this all make sense. Breathing is like a lullaby for the amygdala - but only when it’s practised lots during calm.♥️
When it’s time to do brave, we can’t always be beside them, and we don’t need to be. What we can do is see them and help them feel us holding on, even in absence, while we also believe in their brave.♥️

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