The Popular Painkiller That Reduces Empathy (And Joy)

The Popular Painkiller That Reduces Empathy (And Joy)

Empathy is the heartbeat of healthy relationships. Without it, there is limited scope for connection and understanding – arguments heat up, intimacy cools down, small issues become big ones, and relationships break. New research has made some startling findings in relation to the popular painkiller that reduces empathy.

Empathy is the ability to understand what another person might be feeling or thinking. It involves being able to see things from another person’s point of view, even when it pushes against our own. This means being able to stay curious and open to another person’s experience, while at the same time being able to tap into our own emotional bank to understand and interpret the other person’s experience.

Our own individual stories may differ vastly, but behind every story are feelings that are familiar to all of us. At some point, we have all found ourselves knee-deep in the messiest of human emotions – anguish, loss, shame, grief, fear, jealousy, disappointment. Empathy lets us tap into our own pain to understand the pain of others. New research published in the journal Social Cognitive and Affective Neuroscience has found that our ability to do this may be interrupted by a common painkiller. 

The research found that when participants took acetaminophen, the main ingredient in Tylenol, they were less responsive to the pain and suffering of others, compared to those who did not take a painkiller. (Acetaminophen is also known as paracetamol, the main ingredient in Panadol.)

Acetaminophen is found in more than 600 medicines. It is the most common drug ingredient in the United States and is used by about 23% of American adults each week.

The Popular Painkiller That Reduces Empathy – The Research

The research consisted of a number of separate studies. In the first study, 40 college students were given 1000mg of acetaminophen while the other half were given a placebo. The students had no idea whether they had taken the drug or the placebo.

After the participants had waited for an hour for the drug to take effect, they read about eight individual people who were each experiencing some sort of physical or emotional pain. The stories included one about somebody who had received a cut with a knife that went down to the bone, and another about a person whose father had died. The participants had to rate the pain they believed each person would be experiencing from 1 (no pain) to 5 (worst possible pain).

Those who had taken the acetaminophen rated the severity of pain as lower, compared to those who had taken the placebo.

In the second study, 72 college students took acetaminophen and 72 took the placebo. They were then exposed to four 2-second blasts of white noise from 75 decibels (about the noise of an average vacuum cleaner) to 105 decibels (the noise of a power lawn mower or a live rock concert). They then had to rate their experience of the noise on a scale of 1 (not at all unpleasant) or 10 (extremely unpleasant). They were then asked to imagine the level of pain the same noise blasts might cause someone else.

Compared to those who took the placebo, the people who took the acetaminophen rated the noise blasts as more tolerable for themselves, and more tolerable for others.

Similar results were found when participants were asked to watch an online game which involved two players actively excluding a third person from playing. Each participant had met and socialised with the three people involved (the two playing and the one excluded) briefly before the study. Those who took the acetaminophen rated the pain of the excluded person as less severe, compared to the ratings by those who took the placebo.

We don’t know why acetaminophen is having these effects, but it is concerning … (T)hose who took acetaminophen showed a reduction in empathy. They weren’t as concerned about the rejected person’s hurt feelings.Baldwin Way, co-author of the study and assistant professor of psychology at Ohio State University.

The results support previous research that found the same part of the brain is activated when people experience pain, and when they imagine other people feeling the same pain. It makes sense then, that when medication is taken to reduce a person’s own experience of pain, it will also reduce the ability to feel the pain of other people.

In short bursts, reduced empathy might not seem such a big deal, but it only takes a moment for arguments to fever up.

Empathy is important. If you are having an argument with your spouse and you just took acetaminophen, this research suggests you might be less understanding of what you did to hurt your spouse’s feelings.–Baldwin Way.

Earlier research found that acetaminophen reduces the pain of social rejection (as in the pain of a breakup), but research since has found that that acetaminophen also flattens positive emotions, like joy. 

The researchers are now turning their attention to ibuprofen, another common pain medication, to see if there are similar results.

8 Comments

Monika

This is very interesting. I got onto your website trying yo find connection between my strange reaction to pain. I feel as if any pain, physical or mental, alters my perception of reality and affects my personality. I have rather low pain threshold and am very emotional, to the point of not being able to control my outbursts of emotions – it usually is demonstrated by tears at the slightest emotional trigger.
I’m wondering if there are any articles that you could point me towards, so I can explore this further with my psychotherapist. Thank you for your articles, they help so much!

Reply
Hey Sigmund

Monika I’m pleased the articles are helpful for you. Physical pain and emotional pain activate the same parts of the brain, so what you are describing makes sense. Here is an article that explains the science of that https://www.heysigmund.com/your-body-during-a-breakup/. It is about the pain of a breakup, but it explains the concept and research around the connection between emotional pain and physical pain. Hope it helps.

Reply
Steph

I suspect I am a bit premature with this query but are there any plans afoot to study the effects amongst pregnant women?
In the UK pain relievers such as Paracetamol & Co-codamol (which contains paracetamol) are currently bottom of the list in terms of risk during pregnancy. While your article suggests that the effects on the mother are likely to be short term, what might the effects on a developing foetus be?

Reply
Hey Sigmund

That’s a really good question Steph. I’m not aware of plans to study the effects in pregnant women, but that certainly doesn’t mean that there aren’t any. Will keep an eye out!

Reply
Rick

“The researchers are now turning their attention to ibuprofen.”
What did they find?

Reply
Ann W.

I have to say I have never lacked having a feeling of empathy whenever I have taken Tylenol. But then again, I have known a few people who didn’t take Tylenol or any other drugs/painkillers either OTC or prescribed who lacked empathy. I wonder if there is something else going on; perhaps a gene that makes some people less empathetic in general that somehow converts to complete apathy whenever they take Tylenol or certain other drugs. I think this begs further research.

Reply
Hey Sigmund

The research is very new, but the researchers aren’t saying that Tylenol wipes out empathy. It reduces it, it doesn’t get rid of it. As they point out in the quote in the article, sometimes just a little tip in empathy levels might be enough to change the shape of an argument. It’s an interesting area and I expect there will be plenty more research to come.

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The key to moving kids trough anxiety is helping them know when to retreat into safety, and when to move forward into brave.♥️
When their world feels wobbly, children will look to their closest adults for signs of safety. Our nonverbals will speak the loudest. We’ve been communicating in nonverbals long before words. With every expression, movement, with our posture, our voice, our tone, we’re communicating to them whether we believe they are brave enough and safe enough. 

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If you can hold a calm steady presence it will make it easier for their bodies and brains to pick up on that calm. If they’ve been feeling anxious retreating from something for a while, it will take a while them to trust that they can cope, and that’s okay. The move towards brave doesn’t have to happen quickly. It’s the direction that matters. 

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Few things will stoke anxiety more in an anxious child than unpredictability. One of the ways they might relieve their anxiety is through control. (We can all fall into controlling behaviour when we’re anxious.) This isn’t done to be insensitive or ‘bossy’, even though it might come out that way. It’s done because of their great and very understandable need for predictability and safety.

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Without limits kids have nothing to guide their behaviour. The options become vast and overwhelming. They need to feel like you’ve got them, that you’ve set a safety zone and that within that, they’re fine. Of course they’ll push up against the edges and sometimes they’ll move well outside them – that’s all part of growing up and stretching their wings but even then, the boundaries will offer some sort of necessary guidance. In time, children without limits wil become controlling and demanding – and that just doesn’t end well for anyone.

When they are pushing against your boundaries, let those boundaries be gentle, but firm. Invite their opinions and give space for them to disagree:
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Even the spiciest behaviour will have a valid need behind it. If we can respond to the need behind the behaviour, the behaviour will ease. When this happens, they will be more open to our guidance and influence: ‘What happened?’ ‘What can you do differently next time?’ ‘You’re a great kid, and I know you know that wasn’t okay. How can you put things right?’

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