Happiness and Depression Could Be Steered By the Same Genes

Happiness and Depression Could Be Driven By the Same Genes

Genes are the secret-keepers. Within their tiny walls are so many answers to the whys and the whats of our physical and mental health. Our genetics though, are only one part of our story – and they may not have as much power to write our script as we may have once thought.

The more we learn about mental health, the more we realise the importance of the interaction between nature (genetics) and nurture (the environment). There is no single gene that ‘causes’ mental ill-health. If there was, everyone with the gene variation would go on to develop the symptoms that are associated with it. 

So if genes aren’t the full story, what’s missing?

There are genes that influence the onset of symptoms, but genes are not destiny. The key is the environment. If someone has a genetic vulnerability for mental ill-health, an adverse environment can steer this vulnerability in ways that compromise mental health. What’s fascinating, and gives us reason for optimism, is that a more positive, supportive environment can steer the same genetic vulnerability in ways that strengthen mental health. 

In a study published in the journal, Molecular Psychiatry, researchers have explained that the genes involved in mental ill-health could also nurture greater mental resilience. Someone with a genetic vulnerability to depression, for example, will do worse in a harmful environment than people without the genetic vulnerability, but in healthy, positive environments, they may do better than those without the vulnerability. 

‘If you take a gene that is linked to mental illness, and compare people who have the same genetic variant, it becomes clear that what happens to their mental health is based on their environment.’ – Professor Elaine Fox, Oxford University.

The same gene can work for us or against us. What’s that about?

Researchers suggest that the environment switches on a genetic vulnerability through its influence on our cognitive biases. These are the mental filters that we tend to look at the world through. 

‘Cognitive biases are when people consistently interpret situations through particular mental ‘filters’ – when people have a cognitive bias that emphasizes negative aspects or thoughts, they are more at risk of mental health disorders.’ – Professor Chris Beevers, University of Texas, Austin.

Someone with a negative cognitive bias will be more likely to turn their attention to threat or negative information. In situations that are neutral or ambiguous, a negative cognitive bias will interpret or explain those situations negatively.

If a friend is running late, for example, someone with a negative cognitive bias might interpret this as evidence that the friend doesn’t really want to be there. Someone with a positive cognitive bias, for example, might be more likely to explain the same situation as the friend was unexpectedly held up and that it was nothing to do with wanting to be there. 

Think of cognitive biases as looking through a stained glass window. If the glass is blue, we will see the world outside with a blue tinge. If the glass is covered in dust, we will see the world as a dusty one. If the glass is clear, this will be our view of the world and the people who come close enough to the window for us to notice. Depending on the environment, genes can change the ‘window’ through which we see the world. A positive environment will give us a positive view, a negative one will muddy it.

‘… some genes can make people more sensitive to the effects of their environment – for better or worse … If you have those genes and are in a negative environment, you are likely to develop the negative cognitive biases that lead to mental disorders. If you have those genes but are in a supportive environment, you are likely to develop positive cognitive biases that increase your mental resilience.’ – Professor Elaine Fox.

What is it about an environment that causes breakage?

More research is needed to understand the relationship between genetic vulnerabilities and environmental ‘switches’. There is a call to combine research about mental health genetics and research about cognitive biases. There is plenty of research about each separate field, but after reviewing a number of studies, researchers are convinced that the key to understanding more about our mental health, and more importantly how to manage it, lies in the merging of the two. 

What does it all mean? 

We all have our fault lines – the vulnerabilities that are part of being human. When those vulnerabilities are genetic, they will often stay hidden. Our only clue will be the symptoms they give life to, most likely when our environment gives them a push.

Our genes are our environment are deeply connected. We can’t change our genes, but we can influence our environment. This doesn’t mean that all that is needed for strong mental health is a change of environment. Even if it was that simple – which it’s not – changing the environment isn’t always possible. 

Further research is needed to understand the relationship between genes, the environment, and mental health. What we know for certain is that the environment around us matters, for better or worse. The people around us, the family we grew up in, our physiology, our work culture, the food we eat, the quality and quantity of sleep and exercise we get, the air we breathe, the pollutants and toxins we are exposed to – it all matters.

Anything you can do to make your environment better for you will be important:

  1. Toxic people will contaminate your self-esteem and the way you view the world. Whenever you can, show them the door. Now slam it shut behind them. Now check it to make sure it’s locked. Done? Good. Great. You’ve probably been wanting to that for a while. 
  2. Get plenty of exercise. This will increase vital neurochemicals and help to build the structure of the brain for the better, protecting and promoting stronger mental health. 
  3. Sleep. Your brain loves it like a favourite thing.
  4. Spend time deliberately focusing on positive things. It’s easy to get swamped by the bad, but when you can focus on something that stirs up the feel-good, it will change the structure of your brain for the better. It doesn’t have to be anything big – a text message that makes you happy, a feeling, a photo, a memory – anything that stirs something lovely in you. 20 seconds is enough to start the rewiring. Read more about that here. 

And finally …

Researchers are looking deeper into the combined influence of genetics and the environment on our mental filters. The hope is for a greater understanding of how genetics and the environment interact to affect our mental health. The more we can widen our knowledge, the more this will open up the way for effective treatment and management options, and ways to nurture mental health and mental resilience for all of us.

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We don’t need to protect kids from the discomfort of anxiety.

We’ll want to, but as long as they’re safe (including in their bodies with sensory and physiological needs met), we don’t need to - any more than we need to protect them from the discomfort of seatbelts, bike helmets, boundaries, brushing their teeth.

Courage isn’t an absence of anxiety. It’s the anxiety that makes something brave. Courage is about handling the discomfort of anxiety.

When we hold them back from anxiety, we hold them back - from growth, from discovery, and from building their bravery muscles.

The distress and discomfort that come with anxiety won’t hurt them. What hurts them is the same thing that hurts all of us - feeling alone in distress. So this is what we will protect them from - not the anxiety, but feeling alone in it.

To do this, speak to the anxiety AND the courage. 

This will also help them feel safer with their anxiety. It puts a story of brave to it rather than a story of deficiency (‘I feel like this because there’s something wrong with me,’) or a story of disaster (‘I feel like this because something bad is about to happen.’).

Normalise, see them, and let them feel you with them. This might sound something like:

‘This feels big doesn’t it. Of course you feel anxious. You’re doing something big/ brave/ important, and that’s how brave feels. It feels scary, stressful, big. It feels like anxiety. It feels like you feel right now. I know you can handle this. We’ll handle it together.’

It doesn’t matter how well they handle it and it doesn’t matter how big the brave thing is. The edges are where the edges are, and anxiety means they are expanding those edges.

We don’t get strong by lifting toothpicks. We get strong by lifting as much as we can, and then a little bit more for a little bit longer. And we do this again and again, until that feels okay. Then we go a little bit further. Brave builds the same way - one brave step after another.

It doesn’t matter how long it takes and it doesn’t matter how big the steps are. If they’ve handled the discomfort of anxiety for a teeny while today, then they’ve been brave today. And tomorrow we’ll go again again.♥️
Feeling seen, safe, and cared for is a biological need. It’s not a choice and it’s not pandering. It’s a biological need.

Children - all of us - will prioritise relational safety over everything. 

When children feel seen, safe, and a sense of belonging they will spend less resources in fight, flight, or withdrawal, and will be free to divert those resources into learning, making thoughtful choices, engaging in ways that can grow them.

They will also be more likely to spend resources seeking out those people (their trusted adults at school) or places (school) that make them feel good about themselves, rather than avoiding the people of spaces that make them feel rubbish or inadequate.

Behaviour support and learning support is about felt safety support first. 

The schools and educators who know this and practice it are making a profound difference, not just for young people but for all of us. They are actively engaging in crime prevention, mental illness prevention, and nurturing strong, beautiful little people into strong, beautiful big ones.♥️
Emotion is e-motion. Energy in motion.

When emotions happen, we have two options: express or depress. That’s it. They’re the options.

When your young person (or you) is being swamped by big feelings, let the feelings come.

Hold the boundary around behaviour - keep them physically safe and let them feel their relationship with you is safe, but you don’t need to fix their feelings.

They aren’t a sign of breakage. They’re a sign your child is catalysing the energy. Our job over the next many years is to help them do this respectfully.

When emotional energy is shut down, it doesn’t disappear. It gets held in the body and will come out sideways in response to seemingly benign things, or it will drive distraction behaviours (such as addiction, numbness).

Sometimes there’ll be a need for them to control that energy so they can do what they need to do - go to school, take the sports field, do the exam - but the more we can make way for expression either in the moment or later, the safer and softer they’ll feel in their minds and bodies.

Expression is the most important part of moving through any feeling. This might look like talking, moving, crying, writing, yelling.

This is why you might see big feelings after school. It’s often a sign that they’ve been controlling themselves all day - through the feelings that come with learning new things, being quiet and still, trying to get along with everyone, not having the power and influence they need (that we all need). When they get into the car at pickup, finally those feelings they’ve been holding on to have a safe place to show up and move through them and out of them.

It can be so messy! It takes time to learn how to lasso feelings and words into something unmessy.

In the meantime, our job is to hold a tender, strong, safe place for that emotional energy to move out of them.

Hold the boundary around behaviour where you can, add warmth where you can, and when they are calm talk about what happened and how they might do things differently next time. And be patient. Just because someone tells us how to swing a racket, doesn’t mean we’ll win Wimbledon tomorrow. Good things take time, and loads of practice.♥️
Thank you Adelaide! Thank you for your stories, your warmth, for laughing with me, spaghetti bodying with me (when you know, you know), for letting me scribble on your books, and most of all, for letting me be a part of your world today.

So proud to share the stage with Steve Biddulph, @matt.runnalls ,
@michellemitchell.author, and @nathandubsywant. To @sharonwittauthor - thank you for creating this beautiful, brave space for families to come together and grow stronger.

And to the parents, carers, grandparents - you are extraordinary and it’s a privilege to share the space with you. 

Parenting is big work. Tender, gritty, beautiful, hard. It asks everything of us - our strength, our softness, our growth. We’re raising beautiful little people into beautiful big people, and at the same time, we’re growing ourselves. 

Sometimes that growth feels impatient and demanding - like we’re being wrenched forward before we’re ready, before our feet have found the ground. 

But that’s the nature of growth isn’t it. It rarely waits for permission. It asks only that we keep moving.

And that’s okay. 

There’s no rush. You have time. We have time.

In the meantime they will keep growing us, these little humans of ours. Quietly, daily, deeply. They will grow us in the most profound ways if we let them. And we must let them - for their sake, for our own, and for the ancestral threads that tie us to the generations that came before us, and those that will come because of us. We will grow for them and because of them.♥️
Their words might be messy, angry, sad. They might sound bigger than the issue, or as though they aren’t about the issue at all. 

The words are the warning lights on the dashboard. They’re the signal that something is wrong, but they won’t always tell us exactly what that ‘something’ is. Responding only to the words is like noticing the light without noticing the problem.

Our job isn’t to respond to their words, but to respond to the feelings and the need behind the words.

First though, we need to understand what the words are signalling. This won’t always be obvious and it certainly won’t always be easy. 

At first the signal might be blurry, or too bright, or too loud, or not obvious.

Unless we really understand the problem behind signal - the why behind words - we might inadvertently respond to what we think the problem is, not what the problem actually is. 

Words can be hard and messy, and when they are fuelled by big feelings that can jet from us with full force. It is this way for all of us. 

Talking helps catalyse the emotion, and (eventually) bring the problem into a clearer view.

But someone needs to listen to the talking. You won’t always be able to do this - you’re human too - but when you can, it will be one of the most powerful ways to love them through their storms.

If the words are disrespectful, try:

‘I want to hear you but I love you too much to let you think it’s okay to speak like that. Do you want to try it a different way?’ 

Expectations, with support. Leadership, with warmth. Then, let them talk.

Our job isn’t to fix them - they aren’t broken. Our job is to understand them so we can help them feel seen, safe, and supported through the big of it all. When we do this, we give them what they need to find their way through.♥️

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