New Research will Change the Way We Think About Depression. (Finally!)

New Research will Change the Way We Think About Depression. (Finally!)

The way we have been thinking about depression is broken. Depression is widely considered to be a mental illness – an disorder of the mind – but new research has challenged that, and the findings will change the way we think about and treat depression.

Physical illness rarely carries the same crippling stigma as mental illness. There seems to be a gap between the way we think about the two, with physical illness often garnering more respect and permission to ‘be’. To understand depression in a way that and fosters better treatment options and greater clarity, we need to find out more about what it is – or what it is not.

Enter a team of international researchers, who have gone and done just that. 

The Research – What They Did.

For the very first time, in a comprehensive study lead by a team of researchers from around the world, we have scientific proof that depression is not just a mental disorder but a systemic one that affects the whole body. The massive study, published in the Journal of Clinical Psychiatry involved an analysis of 29 previous studies, comprising a total of 3,961 people.

The researchers were interested in the way depression manifested in the bodies of those individuals. They found that depression affects the whole body on a cellular level. In light of this, the researchers have called for depression to be considered a systemic disease, rather than a mental one.

The results make sense of the longstanding observation that people with depression are also more likely to be diagnosed with cancer and heart disease.

What They Found.

The study revealed that depression was linked to oxidative stress in the body. When compared to people without depression, those who were depressed had elevated levels of malondaldehyde – a compound that indicates oxidative stress.

So what is oxidative stress? Let me explain. Oxidative stress happens when the body overproduces free radicals and then struggles to get rid of them from the body. Free radicals cause damage to critical parts of cells including proteins, DNA and cell membranes. When the free radicals damage these important parts of the cells, the cells aren’t able to function properly. Eventually, they can die.

Free radicals are produced naturally by the body but overproduction can be triggered by stress, pollutants, alcohol, the air we breathe, the food we eat (particularly fried food), the body’s natural immune system response (inflammation) or tobacco smoke. In short, modern living makes us vulnerable.

One of the ways the body detoxifies free radicals is through antioxidants. Antioxidants inhibit oxidisation by scavenging free radicals from the body. When there are too many free radicals floating around and not enough antioxidants to mop them up, the body struggles to keep up with the detoxification of the free radicals. The body comes under oxidative stress and this is when the damage to the cells can spread throughout the body.

What it Means.

The findings open up new avenues for the treatment and prevention of depression. Heal the body and we can heal the mind. 

In their study, the authors conclude that;

‘Results suggest that oxidative stress plays a role in depression and that antidepressant activity may be mediated via improving oxidative stress (and) antioxidant function.’

After receiving the usual treatment for depression, the levels of malondialdehyde (the indicator that the body may be under oxidative stress) decreased, and the levels of antioxidants increased. Eventually, both malondialdehyde and antioxidants were restored to such a level that the bodies of people with depression were indistinguishable from people who did not have depression.

Future Promise.

Depression has long been thought of as a disorder of the mind and this is the way it has been treated. Antidepressants target neurotransmitters in the brain, and though some people find great relief from these, many don’t find relief, or eventually relapse.

It seems that in treating only the mind, we have been getting it spectacularly wrong. The mind and the body are deeply connected. An abundance of scientific research has consistently delivered us the proof. 

Depression is an illness of the whole body, not just the mind. In recent years, the theories around depression being caused by a chemical imbalance in the brain have started to break down.

[irp posts=”1727″ name=”Healing From Depression. The 6 Proven, Non-Medication Ways That Are As Effective as Antidepressants (We Should All Be Doing This!)”] 

We know that when some people are given antidepressants that target serotonin levels in the brain, they find relief. For a long time, this was taken as evidence that a lack of serotonin caused depression. Just because something makes it better, that doesn’t mean that the body is deficient in that ‘something’. This is similar to saying that shyness is caused by a lack of alcohol, or that headaches are caused by a lack of paracetamol, or that fatigue is caused by a lack of caffeine. 

There is another reason the low serotonin/depression-is-all-in-the-head theories are becoming shaky. If one of the symptoms of depression is low serotonin, what causes the low serotonin? The way we have been thinking about depression – as purely a mental illness – stops short of a full explanation.

Antidepressants have given great relief to many people, but there are many who find no relief at all. It’s likely that by treating the chemical imbalance, we are only treating part of the problem. Think of it like treating fatigue with a decent sleep. When fatigued people sleep, they feel less fatigued. Does this mean that fatigue is from a lack of sleep? Sometimes, yes, absolutely. And in these cases, a decent sleep will be exactly what’s needed. Sometimes though, fatigue will be a sign of something else happening in the body – an infection, a virus. In these cases, sleep might help but the relief won’t be lasting because it won’t be treating the cause.

When we change the way we think about depression – as an illness of the whole body, not just an illness of the mind – we open up new possibilities for treatment. The body can heal and so can the mind. This is not new information, but hopefully, with our ever expanding understanding of depression, we can use this old information in new and powerful ways to heal the mind, body and spirit in more enduring and effective ways.

37 Comments

Shiraz

This article is what I was looking for. I do not believe in antidepressants. Taking them for 2 years without much improvement. Will try this method with antioxidents

Reply
Jackheysigmun

Thank you. This makes sense. Ok where can I get help? My psychiatrist certainly won’t buy this.

Reply
Mary

Hi Karen,

You said that, “One of the ways the body detoxifies free radicals is through antioxidants.” What is the best way to get more antioxidants? I always see products advertised in the store.

Reply
Clare

Karen,

I simply love your articles. I have been working in the mental health field for over 20 years and I find your writing reader friendly and inspiring for so many that need a bit of hope.

Reply
Alexandra Della Fera

Speaking of anxiety – as the last post mentioned- does this theory hold true for anxiety disorders as well? Or is there a distinct systemic difference between depression and anxiety?

Reply
Jasmin Beck

Yet again another interesting and informative article, if like me you suffer severely from depression and the medications over 40 years have proved toxic for me-that doesn’t mean they on’t help others.
I have finally found a wonderful psychiatrist who is not using meds with me and is withdrawing me slowly from clonazepam, but due to other issues is keeping it at current level due to severe anxiety and sleep issues. He is using a combination of clonazepam and melatonin to try to help me.

Reply
Ken

This is a wonderful website and I appreciate what you’re doing.

I’ve suffered from depression since I was a teenager, but I didn’t know what was wrong with me until after it cost me my marriage in my 30s. A little over a year ago, at age 58, I finally had enough courage – no, that’s not right – I finally couldn’t stand it any longer and sought help from my GP.

I’ve had long periods when I could simply work through it and eventually feel better. Then it comes back again. This time is the worst since my marriage ended back in 1993.

My GP is great and we’re working on it and I’m better than a year go. My question is: Is there a reliable (and inexpensive) blood test to see which chemicals/amino acids are insufficient? I think it would save a tremendous amount of time.

The serotonin reuptake inhibitors don’t seem to be doing the trick.

Reply
Hey Sigmund

Ken thank you very much for your comment – it means a lot. Your question is a very good one. I’m not sure about the answer. As far as I know, there isn’t an objective way to test for the biomarkers of depression, but a GP would probably be the best person to ask. The direction the depression research is heading in is fairly new, so hopefully there will be new tests and treatment options on the way. You were right the first time when you called it courage. Depression is so depleting and if you don’t know what’s behind it, it can be so confusing and it takes a major push to take the step to find out what’s happening – and you did that. Now it’s about exploring what will work for you to help you find relief from your symptoms.

If the serotonin reuptake inhibitors aren’t working, here are a couple of articles that might be worth reading or discussing with your GP. The first two are about the role of the gut. There is a lot of research that has found that there is a strong connection between the brain and the gut and when the environment of the gut is out, it can compromise mental health https://www.heysigmund.com/our-second-brain-and-stress-anxiety-depression-mood/ and https://www.heysigmund.com/anxiety-depression-gut-bacteria/.

This one talks about other ways to improve depressive symptoms https://www.heysigmund.com/the-non-medication-ways-to-deal-with-depression-that-are-as-effective-as-medication/. In the meantime, know that there is a lot of research happening in the area of depression, and a lot of new avenues being explored. It’s great that you have found a GP you trust and can work with. That partnership can be a really important one. Don’t lose hope – they really are getting closer to figuring out how to beat this.

Reply
Sharon Hutchinson

Hi Ken! I sometimes say I was born depressed, since it was something I’ve suffered with for a long, long time. When the teen years arrived, depression and mood swings took off big time.

After reacting to an antibiotic in a way that supposedly the pharmacists “never heard of”–my depression not only worsened but I began to have audio/visual hallucinations–my psychiatrist was the one who believed me. He said that antibiotics can play awful havoc with our gut flora, and this in turn can effect what and how our brain chemicals react.

There is much truth in this article, and more hope for the future!

Reply
Sarah

Hi there I am a biotechnology student and would love to read the paper that this article refers to if you can maybe email me the authors, year and title. Last week I lost my cousin to depression and it seems to be rife within my family. Reading your article has sparked inspiration in me so thank you for sharing it.

Reply
Juliette

Yup! Even though I’m on meds, they are not truly helping so needed another med to boost my motivation levels to be productive. I hate taking meds and sometimes I forget. Then the panic sets in

Reply
Hey Sigmund

Juliette I completely understand the love-hate relationship with meds. There is so much research happening at the moment that’s bringing us closer to finding better treatment options. Hang in there.

Reply
Kay

Hi, love your insight..
I read an article a couple years ago (I think it was Psychology Today, I was in a waiting room) talking about new findings on the brain because of a new way to study the physical brain itself..
Long story short, the conclusion of the article brought up the idea that depression is also an inflammation in(?) the brain (caused by trauma, physical and mental stress) and they suggested things like Curcumin might reduce depression in up to 80% of people suffering from it..
Have you heard of this? I’ll try to find a link but I’m limited in my computer skills, soo…
Thanks, Kay

Reply
Hey Sigmund

Hi Kay,

I’m not sure about the exact article you’re referring to but there is certainly a ton of research happening at the moment that is pointing to depression being caused by inflammation that could be brought on by things like stress, trauma, illness, allergies, environmental toxins. Here is an article that explains the connection between depression and inflammation https://www.heysigmund.com/activity-restores-vital-neurochemical-protects-anxietyepression/.

Curcumin is an anti-inflammatory and the research shows that it’s great for brain health. Here’s an article about that https://www.heysigmund.com/this-helps-heal-your-brain-and-its-probably-in-your-pantry/. We’re learning a lot about the things we can do to strengthen the brain. The idea that we can actually change our brain has only come about in the last decade or so but it’s changing the way we think about mental health – all for the better. Here are a couple of articles that talk about that, if you are interested:
>> Simple Ways to Supercharge Mental Health and Brain Performance: https://www.heysigmund.com/simple-ways-to-supercharge-brain-health-and-mental-performance/
>> The Non-Medication Ways to Deal With Depression that are as Effective as Medication https://www.heysigmund.com/the-non-medication-ways-to-deal-with-depression-that-are-as-effective-as-medication/

I hope this helps.

Reply
L

This all makes so much sense to me. I have struggled with anxiety and depression for as along as I can remember and it has got worse over the last few years. I have tried soo many different antidepressants and I always have bad side effects from them and have to stop and I’m thinking what is wrong with me!? Am I making it all up!? I cannot see a light at the end, I feel like I am just going to keep getting worse, I’m not living, just struggling and existing. I am a mother of 2 (separated from their dad 3 and half years ago) and being the way I am is no good, I don’t feel like a good mum, I’m always stressed and I shout a lot which I absolutely hate and I don’t want my kids to end up the same as me! I attempted suicide a year and a half ago and I have these thoughts ALOT!! I feel so hopeless and worthless and I just want to be and feel normal!! I had my 2nd son dec 2012, got sterilised in 2013 and then diagnosed with fibromyalgia in 2014. I tried accupuncture last year but its so expensive so I couldn’t continue with the treatment. Can u recommend natural treatment that can help me to feel better?? I get so overwhelmed trying to find things that will work as there’s many conflicting stories and also so many different options and I don’t know which ones are best and actually contain the right ingredients and not all the bad stuff! Sorry I’m not very good at putting my thoughts or explaining things properly, apparently down to ‘brain fog’ from fibro!
Thanks

Reply
Penel

My friend who suffered from depression and anxiety died from a massive heart attack. He had had to decrease his depression meds because they conflicted with his heart meds.
This article explains a lot, as he was trying very hard to eat right, etc.
Thank you.

Reply
Trella

I would like to know about alternative ways of treating depression in light of it being more than just a mental illness and getting away from the traditional antidepressants.

Reply
Hey Sigmund

Trella, there is still so much we don’t know but the research is heading in a really positive direction. If you are on medication, it’s important not to give that up or reduce the dosage without the close supervision of a doctor. Even if you are on medication though, there are things you can do to strengthen your mind and body against depression. Here is some information that might help you https://www.heysigmund.com/the-non-medication-ways-to-deal-with-depression-that-are-as-effective-as-medication/.

Reply
Alexa

Thank you for this article. I remember hearing Andrew Solomon say, during one of his TED Talks, that “the opposite of depression is not happiness; it is vitality.” Suddenly, my lifelong experience with this condition began to make sense. I’m in full agreement that depression is a whole-body, whole-person condition. In my own situation, depression was incited by a two-month premature birth in the late 1950s — the medical protocol of the time forbade parental contact with preemies, so I did not bond with my mother, or with any other adult. My doctor — a gem — and I have discovered, through research, a variant on depression in infants — anaclitic depression, which is also known as “failure to thrive.” The best medicine for my variant has always been, and always will be, body-based. Diet, hydration, walking, gentle movement, restful sleep, and most of all, loving bonds that include lots of touch. I believe there is a strong link between depression — I see it as a functional as well as a structural disorder — and trauma … Unattended grief is also a factor. Social, environmental, and relational breakdowns almost guarantee that depression will result (you speak to this in saying that “modern living makes us vulnerable”) … Its genesis in each person is as unique as a fingerprint … and so is its treatment. Articles such as this inch us closer to a wiser and more compassionate understanding …

Reply
Kerry

I have a daughter that has been struggling with anxiety and depression for the last year. We have not found an antidepressant thhaatt hhas worked yet. She eats pretty healthy. She is currently doing DBT therapy. Are there any other suggestions? She is not a good sleeper so her anxiety medication is suppose to help her with sleep.

Reply
Karen Young

Mindfulness and exercise are really important. They have both been shown by plenty of research to have the capacity to strengthen the brain against anxiety and depression. Here are a couple
Of articles that will explain how they work and why they are so important https://www.heysigmund.com/overcoming-anxiety-mindfulness/ and https://www.heysigmund.com/activity-restores-vital-neurochemical-protects-anxietyepression/.

Mindfulness can also be a way to help her find calm before sleep. I hope your daughter is able to find some relief soon.

Reply
Mimi

If she’s not into athletics, get her into one. One that she enjoys, and will want to do regularly. With others in a supportive environment.

Get her a regular creative outlet, if she doesn’t already have one.

Find her a weekly support group of people her age.

Good luck.

Reply
Kathi

Oh wow! This is so inspiring!!!! I’ve been wondering about this for some time – I’d do anything to stop taking tablets! I was diagnosed with bipolarII one year ago but I’m even questioning that now. Hmm …. thank you so much!

Reply
Hey Sigmund

You’re so welcome Kathi. The the research is really opening up in relation to depression, and it’s making a lot of sense. It’s all good news for possible new treatment options – hopefully we will have some soon. Keep working with your doctor in relation to your tablets, and he or she will be able to keep you in touch with possible new treatment options when they are found.

Reply
Shilpa

Thank you…great article and makes sense completely and yes it needs to be looked at in new light.

Reply
Anne R

Finally! For those of us with a loved one who struggles significantly from depression, and who hasn’t found any benefit from anti-depressants, this info is timely and critical. Hopefully the medical community will quickly get on board. Thank you so much for this article.

Reply
KarenB

I am interested in hearing what people say about this very interesting article.

Reply
Sharon Hutchinson

This makes perfect sense. It is the same with migraines, which are also systemic. When I called a headache specialist, the first question I was asked was “Are you calling about a headache or a migraine?” in this case, the headache is just the most obvious symptom, but actually most other body systems are involved as well.

We are discovering more and more how the entire body is interconnected. Finally!

Reply
Margaret O'Quigley

I have always believed and it is well understood the body and the mind are so connected . It makes perfect sense.
Margaret O’Ouigley
MIACP

Reply

Leave a Reply

Your email address will not be published. Required fields are marked *

Follow Hey Sigmund on Instagram

All kids need the 'the right things' to thrive. The right people, the right motivation, the right encouragement. Out in the world, at school, or wherever they find themselves, kids and teens with anxiety don't need any extra support - they just need their share, but in a way that works for them. 

In a world that tends to turn towards the noise, it can be easy for the ones that tend to stand back and observe and think and take it all in, to feel as though they need to be different - but they don't. Kids and teens who are vulnerable to anxiety tend to have a different and wonderful way of looking at the world. They're compassionate, empathic, open-hearted, brave and intelligent. They're exactly the people the world needs. The last thing we want is for them to think they need to be anyone different to who they are.

#parenting #anxietysupport #childanxietyawareness #mindfulparenting #parent #heywarrior #heysigmund
Sometimes silence means 'I don't have anything to say.' Sometimes it means, 'I have plenty to say but I don't want to share it right here and right now.'

We all need certain things to feel safe enough to put ourselves into the world. Kids with anxiety are thoughtful, observant and insightful, and their wisdom will always have the potential to add something important to the world for all of us. Until they have a felt sense of safety though, we won’t see it.

This safety will only happen through relationship. This isn’t a child thing, or an anxiety thing. It’s a human thing. We’re all wired to feel safest when we’re connected to the people around us. For children it starts with the adult in the room.

We can pour all the resources we want into learning support, or behaviour management, but until children have a felt sense of safety and connection with the adult in the room, the ‘thinking brain’ won’t be available. This is the frontal cortex, and it’s the part of the brain needed for learning, deliberate decisions, thinking through consequences, rational thinking. During anxiety, it’s sent offline.

Anxiety is not about what is actually safe, but about what the brain perceives. A child can have the safest, most loving, brilliant teacher, but until there is a felt sense of connection with that teacher (or another adult in the room), anxiety will interrupt learning, behaviour, and their capacity to show the very best of what they can do. And what they can do will often be surprising - insightful, important, beautiful things.

But relationships take time. Safety and trust take time. The teachers who take this time are the ones who will make the world feel safer for these children - all children, and change their world in important, enduring ways. This is when learning will happen. It’s when we’ll stop losing children who fly under the radar, or whose big behaviour takes them out of the classroom, or shifts the focus to the wrong things (behaviour, learning, avoidance, over relationships).

The antidote to anxiety is trust, and the greatest way to support learning and behaviour is with safe, warm, loving relationships. It’s just how it is, and there are no shortcuts.
In uncertain times, one thing that is certain is the profound power of you to help their world feel safe enough. You are everything to them and however scary the world feels, the safety of you will always feel bigger. 

When the world feels fragile, they will look to us for strength. When it feels unpredictable, they will look to us for calm. When they feel small, we can be their big. 

Our children are wired to feel safe when they are connected and close to us. That closeness doesn’t always have to mean physical proximity, but of course that will be their favourite. Our words can build their safe base, “I know this feels scary love, and I know we will be okay.” And our words can become their wings, “I can hear how worried you are, and I know you are brave enough. You were built for this my love. What can you do that would be brave right now?”

We might look for the right things to do or the right things to say to make things better for them, but the truth of it all is the answer has always been you. Your warmth, your validation, your presence, your calm, your courage. You have the greatest power to help them feel big enough. You don’t have to look for it or reach for it - it’s there, in you. Everything you need to help them feel safe enough and brave enough is in you. 

This doesn’t mean never feeling scared ourselves. It’s absolutely okay to feel whatever we feel. What it means is allowing it to be, and adding in what we can. Not getting over it, but adding into it - adding strength, calm, courage. So we feel both - anxious and strong, uncertain and determined, scared and safe ‘enough’. 

When our children see us move through our own anxiety, restlessness, or uncertainty with courage, it opens the way for them to do the same. When our hearts are brave enough and calm enough, our children will catch this, and when they do, their world will feel safe enough and they will feel big enough.
The temptation to lift our kiddos out of the way of anxiety can be spectacular. Here's the rub though - avoidance has a powerful way of teaching them that the only way to feel safe is to avoid. This makes sense, but it can shrink their world. 

We also don't want to go the other way, and meet their anxiety by telling them there's nothing to worry about. They won't believe it anyway. The option is to ride the wave with them. Breathe, be still, and stay in the moment so they can find their way there too. 

This is hard - an anxious brain will haul them into the future and try to buddy them up with plenty of 'what-ifs' - the raging fuel for anxiety. Let them know you get it, that you see them, and that you know they can do this. They won't buy it straight away, and that's okay. The brain learns from experience, so the more they are brave, the more they are brave - and we know they are brave.

 #parenting #positiveparenting #parenthood #parentingtips #childdevelopment #anxietyinchildren #neuronurtured #childanxiety #parentingadvice #heywarrior #anxietysupport #anxietyawareness #mindfulparenting #positiveparentingtips #parentingtip #neurodevelopment
To do this, we will often need to ‘go first’ with calm and courage. This will mean calming our own anxiety enough, so we can lead them towards things that are good for them, rather than supporting their avoidance of things that feel too big, but which are important or meaningful. 

The very thing that makes you a wonderful parent, can also get in the way of moving them through anxiety. As their parent, you were built to feel distress at their distress. This distress works to mobilise you to keep them safe. This is how it’s meant to work. The problem is that sometimes, anxiety can show up in our children when it there is no danger, and no need to protect. 

Of course sometimes there is a very real need to keep our children safe, and to support them in the retreat from danger. Sometimes though, the greatest things we can do for them is support their move towards the things that are important a or meaningful, but which feel too big in the moment. One of the things that makes anxiety so tough to deal with is that it can look the same whether it is in response to a threat, or in response to things that will flourish them. 

When anxiety happens in the absence of threat, it can move us to (over)protect them from the things that will be good for them (but which register as threat). I’ve done it so many times myself. We’re human, and the pull to move our children out of the way of the things that are causing their distress will be seismic. The key is knowing when the anxiety is in response to a real threat (and to hold them back from danger) and when it is in response to something important and meaningful (and to gently support them forward). The good news is that you were built to move towards through both - courage and safety. The key to strengthening them is knowing which one when - and we don’t have to get it right every time.♥️

Pin It on Pinterest